A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks

Puthiyavalappil Rasin; Jebiti Haribabu; Kailas Mahipal Malappuram; Vipin Manakkadan; Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam; Cesar Echeverria; Anandaram Sreekanth

doi:10.1016/j.jphotochem.2022.114493

A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks

Puthiyavalappil Rasin, Jebiti Haribabu, Kailas Mahipal Malappuram, Vipin Manakkadan, Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Cesar Echeverria, Anandaram Sreekanth

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A pyrene-based fluorescence sensor PyAP [(Z)-2-((pyren-1-ylmethylene)amino)phenol] was developed by a simple Schiff base reaction. In the presence of other metal ions, the PyAP fluorescence chemosensor recognizes only Ga³⁺ ions. Additionally, PyAP showed good selectivity and sensitivity for the detection of Ga³⁺. In a solution containing DMSO/H₂O (2:8, v/v) the binding constant for PyAP with Ga³⁺ was 7.03 × 10⁴ M⁻¹, and the detection limits were 3.35 nM. The quantum yield for PyAP and PyAP-Ga³⁺ was calculated and found to be 0.0006 and 0.227. This chemosensor PyAP was based on the photo-induced electron transfer (PET) mechanism, which was further validated by DFT studies. The capacity of PyAP to specifically detect Ga³⁺ in living cells and its cell permeability were both validated by live cell imaging in T24 cells. Finally, the chemosensor PyAP was offered applications for molecular logic gates and keypad locks.

Original language	English
Article number	114493
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	437
DOIs	https://doi.org/10.1016/j.jphotochem.2022.114493
State	Published - 1 Mar 2023
Externally published	Yes

Keywords

Chemosensor
Live cell image
Logic gates
MEP
Molecular keypad

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10.1016/j.jphotochem.2022.114493

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Rasin, P., Haribabu, J., Malappuram, K. M., Manakkadan, V., Palakkeezhillam, V. N. V., Echeverria, C., & Sreekanth, A. (2023). A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks. Journal of Photochemistry and Photobiology A: Chemistry, 437, Article 114493. https://doi.org/10.1016/j.jphotochem.2022.114493

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title = "A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks",

abstract = "A pyrene-based fluorescence sensor PyAP [(Z)-2-((pyren-1-ylmethylene)amino)phenol] was developed by a simple Schiff base reaction. In the presence of other metal ions, the PyAP fluorescence chemosensor recognizes only Ga3+ ions. Additionally, PyAP showed good selectivity and sensitivity for the detection of Ga3+. In a solution containing DMSO/H2O (2:8, v/v) the binding constant for PyAP with Ga3+ was 7.03 × 104 M−1, and the detection limits were 3.35 nM. The quantum yield for PyAP and PyAP-Ga3+ was calculated and found to be 0.0006 and 0.227. This chemosensor PyAP was based on the photo-induced electron transfer (PET) mechanism, which was further validated by DFT studies. The capacity of PyAP to specifically detect Ga3+ in living cells and its cell permeability were both validated by live cell imaging in T24 cells. Finally, the chemosensor PyAP was offered applications for molecular logic gates and keypad locks.",

keywords = "Chemosensor, Live cell image, Logic gates, MEP, Molecular keypad",

author = "Puthiyavalappil Rasin and Jebiti Haribabu and Malappuram, {Kailas Mahipal} and Vipin Manakkadan and Palakkeezhillam, {Vishnunarayanan Namboothiri Vadakkedathu} and Cesar Echeverria and Anandaram Sreekanth",

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year = "2023",

month = mar,

day = "1",

doi = "10.1016/j.jphotochem.2022.114493",

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Rasin, P, Haribabu, J, Malappuram, KM, Manakkadan, V, Palakkeezhillam, VNV, Echeverria, C & Sreekanth, A 2023, 'A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks', Journal of Photochemistry and Photobiology A: Chemistry, vol. 437, 114493. https://doi.org/10.1016/j.jphotochem.2022.114493

A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks. / Rasin, Puthiyavalappil; Haribabu, Jebiti; Malappuram, Kailas Mahipal et al.
In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 437, 114493, 01.03.2023.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks

AU - Rasin, Puthiyavalappil

AU - Haribabu, Jebiti

AU - Malappuram, Kailas Mahipal

AU - Manakkadan, Vipin

AU - Palakkeezhillam, Vishnunarayanan Namboothiri Vadakkedathu

AU - Echeverria, Cesar

AU - Sreekanth, Anandaram

PY - 2023/3/1

Y1 - 2023/3/1

N2 - A pyrene-based fluorescence sensor PyAP [(Z)-2-((pyren-1-ylmethylene)amino)phenol] was developed by a simple Schiff base reaction. In the presence of other metal ions, the PyAP fluorescence chemosensor recognizes only Ga3+ ions. Additionally, PyAP showed good selectivity and sensitivity for the detection of Ga3+. In a solution containing DMSO/H2O (2:8, v/v) the binding constant for PyAP with Ga3+ was 7.03 × 104 M−1, and the detection limits were 3.35 nM. The quantum yield for PyAP and PyAP-Ga3+ was calculated and found to be 0.0006 and 0.227. This chemosensor PyAP was based on the photo-induced electron transfer (PET) mechanism, which was further validated by DFT studies. The capacity of PyAP to specifically detect Ga3+ in living cells and its cell permeability were both validated by live cell imaging in T24 cells. Finally, the chemosensor PyAP was offered applications for molecular logic gates and keypad locks.

AB - A pyrene-based fluorescence sensor PyAP [(Z)-2-((pyren-1-ylmethylene)amino)phenol] was developed by a simple Schiff base reaction. In the presence of other metal ions, the PyAP fluorescence chemosensor recognizes only Ga3+ ions. Additionally, PyAP showed good selectivity and sensitivity for the detection of Ga3+. In a solution containing DMSO/H2O (2:8, v/v) the binding constant for PyAP with Ga3+ was 7.03 × 104 M−1, and the detection limits were 3.35 nM. The quantum yield for PyAP and PyAP-Ga3+ was calculated and found to be 0.0006 and 0.227. This chemosensor PyAP was based on the photo-induced electron transfer (PET) mechanism, which was further validated by DFT studies. The capacity of PyAP to specifically detect Ga3+ in living cells and its cell permeability were both validated by live cell imaging in T24 cells. Finally, the chemosensor PyAP was offered applications for molecular logic gates and keypad locks.

KW - Chemosensor

KW - Live cell image

KW - Logic gates

KW - MEP

KW - Molecular keypad

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DO - 10.1016/j.jphotochem.2022.114493

M3 - Article

AN - SCOPUS:85144473466

SN - 1010-6030

VL - 437

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

M1 - 114493

ER -

A “turn-on” fluorescent chemosensor for the meticulous detection of gallium (III) ion and its use in live cell imaging, logic gates and keypad locks

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