TY - JOUR
T1 - Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease
AU - Hurley, Michael J.
AU - Urra, Claudio
AU - Garduno, B. Maximiliano
AU - Bruno, Agostino
AU - Kimbell, Allison
AU - Wilkinson, Brent
AU - Marino-Buslje, Cristina
AU - Ezquer, Marcelo
AU - Ezquer, Fernando
AU - Aburto, Pedro F.
AU - Poulin, Elie
AU - Vasquez, Rodrigo A.
AU - Deacon, Robert
AU - Avila, Ariel
AU - Altimiras, Francisco
AU - Whitney Vanderklish, Peter
AU - Zampieri, Guido
AU - Angione, Claudio
AU - Constantino, Gabriele
AU - Holmes, Todd C.
AU - Coba, Marcelo P.
AU - Xu, Xiangmin
AU - Cogram, Patricia
N1 - Publisher Copyright:
Copyright © 2022 Hurley, Urra, Garduno, Bruno, Kimbell, Wilkinson, Marino-Buslje, Ezquer, Ezquer, Aburto, Poulin, Vasquez, Deacon, Avila, Altimiras, Whitney Vanderklish, Zampieri, Angione, Constantino, Holmes, Coba, Xu and Cogram.
PY - 2022/6/30
Y1 - 2022/6/30
N2 - The degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E (Apoe) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.
AB - The degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E (Apoe) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.
KW - aging
KW - Alzheimer's disease
KW - amyloids
KW - APOE
KW - drug development
KW - genome
KW - lipid droplets
KW - Octodon degus
UR - http://www.scopus.com/inward/record.url?scp=85134466446&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2022.894994
DO - 10.3389/fnagi.2022.894994
M3 - Article
AN - SCOPUS:85134466446
SN - 1663-4365
VL - 14
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 894994
ER -
