TY - JOUR
T1 - Structural antitumoral activity relationships of synthetic chalcones
AU - Echeverria, Cesar
AU - Santibañez, Juan Francisco
AU - Donoso-Tauda, Oscar
AU - Escobar, Carlos A.
AU - Ramirez-Tagle, Rodrigo
PY - 2009/1
Y1 - 2009/1
N2 - Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.
AB - Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.
KW - Antitumoral activity
KW - DFT
KW - Structure-activity relationships
UR - http://www.scopus.com/inward/record.url?scp=59649100854&partnerID=8YFLogxK
U2 - 10.3390/ijms10010221
DO - 10.3390/ijms10010221
M3 - Article
C2 - 19333443
AN - SCOPUS:59649100854
SN - 1422-0067
VL - 10
SP - 221
EP - 231
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 1
ER -
