Medicine and Dentistry 
                            
                                    
                                        
                                            
                                                
    
        
             
            Add on Therapy 
            16% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Albumin 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Albuminuria 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Alternative Complement Pathway C3 C5 Convertase 
            64% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Antidiabetic Agent 
            48% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Apolipoprotein E 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Atherogenesis 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Clinical Feature 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Clinical Research 
            16% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Complication of Diabetes 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Complications of Diabetes Mellitus 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Diabetes Mellitus 
            60% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Endothelial Nitric Oxide Synthase 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Fat Droplet 
            32% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Heme 
            53% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Hepatocyte 
            32% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Inflammatory Infiltrate 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Intravascular Hemolysis 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            JAK-STAT Signaling 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Janus Kinase 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Kidney Tissue 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Leptin Deficiency 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Leptin Receptor 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipid Metabolism 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipidomics 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipogenesis 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipophagocytosis 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipotoxicity 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Mesenteric Artery 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Metabolic Dysfunction-Associated Steatotic Liver Disease 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Microvascular Complication 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Myography 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nephropathy 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nitric Oxide Synthase 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Non-Alcoholic Fatty Liver Disease 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nonalcoholic Fatty Liver 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nuclear Factor 
            64% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Ob/Ob Mouse 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Phosphotransferase 
            48% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Protein Tertiary Structure 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Renal Replacement 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Renal Replacement Therapy 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Semaglutide 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Steatohepatitis 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Streptozocin 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Suppressor of Cytokine Signaling 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Toll Like Receptor 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Transcription Factor Nrf2 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Vascular Smooth Muscle Cell 
            26% 
         
     
    
 
                                            
                                        
                                     
                            
                            
                         
                    
                        
                            Pharmacology, Toxicology and Pharmaceutical Science 
                            
                                    
                                        
                                            
                                                
    
        
             
            2 (2 Chlorophenyl) 4 [3 (Dimethylamino)phenyl] 5 Methyl 1h pyrazolo[4,3 C]pyridine 3,6(2h,5h) Dione 
            14% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Add on Therapy 
            16% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Albuminuria 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Antidiabetic Agent 
            48% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Apolipoprotein E 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Atherogenesis 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Cell Adhesion Proteins 
            13% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Chemokine 
            13% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Chronic Kidney Failure 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Clinical Feature 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Clinical Research 
            16% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Db/Db Mouse 
            10% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Diabetes Mellitus 
            60% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Diabetic Complication 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Diosmin 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Disease Course 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            End Stage Renal Disease 
            13% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Endothelial Nitric Oxide Synthase 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Fatty Liver 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Heme 
            53% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Hemodialysis 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Hyperinsulinemia 
            13% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Inflammatory Infiltrate 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Intravascular Hemolysis 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            JAK-STAT Signaling 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Janus Kinase 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Kidney Disease 
            100% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Kidney Fibrosis 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Leptin Deficiency 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Leptin Receptor 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipotoxicity 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Liver Dysfunction 
            10% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Liver Injury 
            10% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            microRNA 
            13% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            microRNA 132 
            13% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            microRNA 34a 
            13% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Natural Antioxidant 
            16% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nephritis 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nitric Oxide Synthase 
            26% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Ob/Ob Mouse 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Oral Administration 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Premature Mortality 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Semaglutide 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Streptozotocin 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Suppressor of Cytokine Signaling 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Tolerability 
            16% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Toll Like Receptor 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Transcription Factor Nrf2 
            100% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Tumor Suppressor Protein 
            13% 
         
     
    
 
                                            
                                        
                                     
                            
                            
                         
                    
                        
                            Immunology and Microbiology 
                            
                                    
                                        
                                            
                                                
    
        
             
            Angiogenesis 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Apolipoprotein E 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Body Fat 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Db/Db Mouse 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Effective Concentration 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Epithelium Cell 
            8% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Erythrocyte 
            7% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Experimental Model 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Fat Mass 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Fatty Acid 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Glucagon-Like Peptide-1 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Glucose Blood Level 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Heme 
            53% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Immunoglobulin Enhancer Binding Protein 
            8% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Inflammation Response 
            10% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Kidney Function 
            8% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Kidney Transplantation 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Knockout Mouse 
            8% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Leptin Receptor 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipid Composition 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Lipid Liver Level 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Mental Health 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Mesenteric Artery 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            NADPH Oxidase 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Necroptosis 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nephritis 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Nitric Oxide Synthase 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Ob/Ob Mouse 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Oncogene 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Oxidative Stress 
            20% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Preclinical Study 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Premature Mortality 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Pretreatment 
            8% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Transcription Factor 
            10% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Transcription Factor Nrf2 
            80% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Vascular Smooth Muscle Cell 
            40% 
         
     
    
 
                                            
                                        
                                            
                                                
    
        
             
            Wild Type Mouse 
            8%