Preparation and characterization of a new polymer/pharmaceutical-based composite. Part I: Meloxicam

Franco M. Rabagliati; Paula A. Zapata; G. Pedro Orihuela; Paula Galvez; Daniel Canales; Hugo Cardenas

doi:10.1007/s00289-014-1252-9

Preparation and characterization of a new polymer/pharmaceutical-based composite. Part I: Meloxicam

Franco M. Rabagliati, Paula A. Zapata, G. Pedro Orihuela, Paula Galvez, Daniel Canales, Hugo Cardenas

Universidad de Santiago de Chile

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

Composites of low-density polyethylene (LDPE), poly(ethylene-co-vinyl acetate) (EVA), poly(ethylene-co-octadecene), and an LDPE/EVA blend were prepared with different amounts of meloxicam (1, 3 and 5 wt %) by the melt blending process. Meloxicam was homogenously dispersed in polymer matrices. The polymer–meloxicam composites showed thermal behavior and thermal characteristics similar to those of the original polymers. Meloxicam release from the composites was examined in vitro for 50 days. The composites were incubated in phosphate-buffered solution and meloxicam concentration was determined by high-performance liquid chromatography. The prolonged release of the drug indicates that meloxicam-loaded plastic rings offer potential for control of reproduction and chronic inflammatory conditions.

Idioma original	Inglés
Páginas (desde-hasta)	3323-3331
Número de páginas	9
Publicación	Polymer Bulletin
Volumen	71
N.º	12
DOI	https://doi.org/10.1007/s00289-014-1252-9
Estado	Publicada - dic. 2014
Publicado de forma externa	Sí

Acceder al documento

10.1007/s00289-014-1252-9

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{2c81e14870474d98b121ea97ac556071,

title = "Preparation and characterization of a new polymer/pharmaceutical-based composite. Part I: Meloxicam",

abstract = "Composites of low-density polyethylene (LDPE), poly(ethylene-co-vinyl acetate) (EVA), poly(ethylene-co-octadecene), and an LDPE/EVA blend were prepared with different amounts of meloxicam (1, 3 and 5 wt %) by the melt blending process. Meloxicam was homogenously dispersed in polymer matrices. The polymer–meloxicam composites showed thermal behavior and thermal characteristics similar to those of the original polymers. Meloxicam release from the composites was examined in vitro for 50 days. The composites were incubated in phosphate-buffered solution and meloxicam concentration was determined by high-performance liquid chromatography. The prolonged release of the drug indicates that meloxicam-loaded plastic rings offer potential for control of reproduction and chronic inflammatory conditions.",

keywords = "Composites, Drug release composites, Meloxicam, Ovulation inhibition, Polymer blends, Polymer synthesis, Vaginal ring",

author = "Rabagliati, {Franco M.} and Zapata, {Paula A.} and Orihuela, {G. Pedro} and Paula Galvez and Daniel Canales and Hugo Cardenas",

note = "Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",

year = "2014",

month = dec,

doi = "10.1007/s00289-014-1252-9",

language = "English",

volume = "71",

pages = "3323--3331",

journal = "Polymer Bulletin",

issn = "0170-0839",

number = "12",

}

TY - JOUR

T1 - Preparation and characterization of a new polymer/pharmaceutical-based composite. Part I

T2 - Meloxicam

AU - Rabagliati, Franco M.

AU - Zapata, Paula A.

AU - Orihuela, G. Pedro

AU - Galvez, Paula

AU - Canales, Daniel

AU - Cardenas, Hugo

PY - 2014/12

Y1 - 2014/12

N2 - Composites of low-density polyethylene (LDPE), poly(ethylene-co-vinyl acetate) (EVA), poly(ethylene-co-octadecene), and an LDPE/EVA blend were prepared with different amounts of meloxicam (1, 3 and 5 wt %) by the melt blending process. Meloxicam was homogenously dispersed in polymer matrices. The polymer–meloxicam composites showed thermal behavior and thermal characteristics similar to those of the original polymers. Meloxicam release from the composites was examined in vitro for 50 days. The composites were incubated in phosphate-buffered solution and meloxicam concentration was determined by high-performance liquid chromatography. The prolonged release of the drug indicates that meloxicam-loaded plastic rings offer potential for control of reproduction and chronic inflammatory conditions.

AB - Composites of low-density polyethylene (LDPE), poly(ethylene-co-vinyl acetate) (EVA), poly(ethylene-co-octadecene), and an LDPE/EVA blend were prepared with different amounts of meloxicam (1, 3 and 5 wt %) by the melt blending process. Meloxicam was homogenously dispersed in polymer matrices. The polymer–meloxicam composites showed thermal behavior and thermal characteristics similar to those of the original polymers. Meloxicam release from the composites was examined in vitro for 50 days. The composites were incubated in phosphate-buffered solution and meloxicam concentration was determined by high-performance liquid chromatography. The prolonged release of the drug indicates that meloxicam-loaded plastic rings offer potential for control of reproduction and chronic inflammatory conditions.

KW - Composites

KW - Drug release composites

KW - Meloxicam

KW - Ovulation inhibition

KW - Polymer blends

KW - Polymer synthesis

KW - Vaginal ring

UR - http://www.scopus.com/inward/record.url?scp=84920062762&partnerID=8YFLogxK

U2 - 10.1007/s00289-014-1252-9

DO - 10.1007/s00289-014-1252-9

M3 - Article

AN - SCOPUS:84920062762

SN - 0170-0839

VL - 71

SP - 3323

EP - 3331

JO - Polymer Bulletin

JF - Polymer Bulletin

IS - 12

ER -

Preparation and characterization of a new polymer/pharmaceutical-based composite. Part I: Meloxicam

Resumen

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto