Preparation and characterization of some polymer/pharmaceutical-based composites. Part. II ivermectin

Franco M. Rabagliati; Marcela Saavedra; Paula Galvez; Daniel A. Canales; G. Pedro Orihuela; Paula A. Zapata; Hugo G. Cárdenas

doi:10.1007/s00289-017-2024-0

Preparation and characterization of some polymer/pharmaceutical-based composites. Part. II ivermectin

Franco M. Rabagliati, Marcela Saavedra, Paula Galvez, Daniel A. Canales, G. Pedro Orihuela, Paula A. Zapata, Hugo G. Cárdenas

Universidad de Santiago de Chile

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

Composites of low-density polyethylene, LDPE, poly(ethylene-co-vinyl acetate), EVA, and LDPE/EVA 70/30 and 50/50% (weight) blend plus ivermectin (1 and 3% weight) were prepared through the melt-blending process. Ivermectin resulted homogenously dispersed in polymer matrices. The polymer/ivermectin composites showed thermal behavior similar to those of the original polymer matrices. Ivermectin release from the composites, was examined in vitro for various lengths of time and their release percentages were determined by photometric UV spectroscopy and their release percentages reported. The prolonged release of the drug indicates that ivermectin-loaded film offer potential application to control inflammatory events and also antiparasitic properties.

Idioma original	Inglés
Páginas (desde-hasta)	415-425
Número de páginas	11
Publicación	Polymer Bulletin
Volumen	75
N.º	1
DOI	https://doi.org/10.1007/s00289-017-2024-0
Estado	Publicada - 1 ene. 2018
Publicado de forma externa	Sí

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abstract = "Composites of low-density polyethylene, LDPE, poly(ethylene-co-vinyl acetate), EVA, and LDPE/EVA 70/30 and 50/50% (weight) blend plus ivermectin (1 and 3% weight) were prepared through the melt-blending process. Ivermectin resulted homogenously dispersed in polymer matrices. The polymer/ivermectin composites showed thermal behavior similar to those of the original polymer matrices. Ivermectin release from the composites, was examined in vitro for various lengths of time and their release percentages were determined by photometric UV spectroscopy and their release percentages reported. The prolonged release of the drug indicates that ivermectin-loaded film offer potential application to control inflammatory events and also antiparasitic properties.",

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AU - Rabagliati, Franco M.

AU - Saavedra, Marcela

AU - Galvez, Paula

AU - Canales, Daniel A.

AU - Orihuela, G. Pedro

AU - Zapata, Paula A.

AU - Cárdenas, Hugo G.

PY - 2018/1/1

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N2 - Composites of low-density polyethylene, LDPE, poly(ethylene-co-vinyl acetate), EVA, and LDPE/EVA 70/30 and 50/50% (weight) blend plus ivermectin (1 and 3% weight) were prepared through the melt-blending process. Ivermectin resulted homogenously dispersed in polymer matrices. The polymer/ivermectin composites showed thermal behavior similar to those of the original polymer matrices. Ivermectin release from the composites, was examined in vitro for various lengths of time and their release percentages were determined by photometric UV spectroscopy and their release percentages reported. The prolonged release of the drug indicates that ivermectin-loaded film offer potential application to control inflammatory events and also antiparasitic properties.

AB - Composites of low-density polyethylene, LDPE, poly(ethylene-co-vinyl acetate), EVA, and LDPE/EVA 70/30 and 50/50% (weight) blend plus ivermectin (1 and 3% weight) were prepared through the melt-blending process. Ivermectin resulted homogenously dispersed in polymer matrices. The polymer/ivermectin composites showed thermal behavior similar to those of the original polymer matrices. Ivermectin release from the composites, was examined in vitro for various lengths of time and their release percentages were determined by photometric UV spectroscopy and their release percentages reported. The prolonged release of the drug indicates that ivermectin-loaded film offer potential application to control inflammatory events and also antiparasitic properties.

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Preparation and characterization of some polymer/pharmaceutical-based composites. Part. II ivermectin

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