Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

Objective: To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD. Methods: Seventy-four subjects were included, 39 with COPD (age 69 ± 7 years; female 41%) and 35 for control group (age 69 ± 7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph. Results: COPD severity (GOLD ≥ 3) and pulmonary function were associated with sulfhydryl group and AOPP (P ≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (P =.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P <.0001). Conclusion: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD.