Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

W. A. Sepúlveda Loyola; F. Vilaça Cavallari Machado; L. Araújo de Castro; T. Hissnauer Leal Baltus; N. Rampazzo Morelli; K. Landucci Bonifácio; A. A. Morita; A. P. Michelin; D. Sabbatini Barbosa; V. S. Probst

doi:10.1016/j.rce.2019.04.007

Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

Título traducido de la contribución: ¿Está el estrés oxidativo asociado a la gravedad de la enfermedad, a la función pulmonar y al síndrome metabólico en la enfermedad pulmonar obstructiva crónica?

W. A. Sepúlveda Loyola, F. Vilaça Cavallari Machado, L. Araújo de Castro, T. Hissnauer Leal Baltus, N. Rampazzo Morelli, K. Landucci Bonifácio, A. A. Morita, A. P. Michelin, D. Sabbatini Barbosa, V. S. Probst

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11 Citas (Scopus)

Resumen

Objective: To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD. Methods: Seventy-four subjects were included, 39 with COPD (age 69 ± 7 years; female 41%) and 35 for control group (age 69 ± 7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph. Results: COPD severity (GOLD ≥ 3) and pulmonary function were associated with sulfhydryl group and AOPP (P ≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (P =.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P <.0001). Conclusion: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD.

Título traducido de la contribución	¿Está el estrés oxidativo asociado a la gravedad de la enfermedad, a la función pulmonar y al síndrome metabólico en la enfermedad pulmonar obstructiva crónica?
Idioma original	Inglés
Páginas (desde-hasta)	477-484
Número de páginas	8
Publicación	Revista Clinica Espanola
Volumen	219
N.º	9
DOI	https://doi.org/10.1016/j.rce.2019.04.007
Estado	Publicada - dic. 2019
Publicado de forma externa	Sí

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10.1016/j.rce.2019.04.007

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Sepúlveda Loyola, W. A., Vilaça Cavallari Machado, F., Araújo de Castro, L., Hissnauer Leal Baltus, T., Rampazzo Morelli, N., Landucci Bonifácio, K., Morita, A. A., Michelin, A. P., Sabbatini Barbosa, D., & Probst, V. S. (2019). Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease? Revista Clinica Espanola, 219(9), 477-484. https://doi.org/10.1016/j.rce.2019.04.007

@article{f454597c67fa4974a19c37b144f49ba2,

title = "Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?",

abstract = "Objective: To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD. Methods: Seventy-four subjects were included, 39 with COPD (age 69 ± 7 years; female 41%) and 35 for control group (age 69 ± 7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph. Results: COPD severity (GOLD ≥ 3) and pulmonary function were associated with sulfhydryl group and AOPP (P ≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (P =.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P <.0001). Conclusion: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD.",

keywords = "Chronic obstructive pulmonary disease, Metabolic syndrome, Oxidative stress",

author = "{Sep{\'u}lveda Loyola}, {W. A.} and {Vila{\c c}a Cavallari Machado}, F. and {Ara{\'u}jo de Castro}, L. and {Hissnauer Leal Baltus}, T. and {Rampazzo Morelli}, N. and {Landucci Bonif{\'a}cio}, K. and Morita, {A. A.} and Michelin, {A. P.} and {Sabbatini Barbosa}, D. and Probst, {V. S.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Espa{\~n}a, S.L.U. and Sociedad Espa{\~n}ola de Medicina Interna (SEMI)",

year = "2019",

month = dec,

doi = "10.1016/j.rce.2019.04.007",

language = "English",

volume = "219",

pages = "477--484",

journal = "Revista Clinica Espanola",

issn = "0014-2565",

number = "9",

}

Sepúlveda Loyola, WA, Vilaça Cavallari Machado, F, Araújo de Castro, L, Hissnauer Leal Baltus, T, Rampazzo Morelli, N, Landucci Bonifácio, K, Morita, AA, Michelin, AP, Sabbatini Barbosa, D & Probst, VS 2019, 'Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?', Revista Clinica Espanola, vol. 219, n.º 9, pp. 477-484. https://doi.org/10.1016/j.rce.2019.04.007

Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease? / Sepúlveda Loyola, W. A.; Vilaça Cavallari Machado, F.; Araújo de Castro, L. et al.
En: Revista Clinica Espanola, Vol. 219, N.º 9, 12.2019, p. 477-484.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva