Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells

Rodrigo Ramirez-Tagle; Leonor Alvarado-Soto; Juan F. Santibanez; Cesar Echeverria

doi:10.55815/417980

Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells

Rodrigo Ramirez-Tagle, Leonor Alvarado-Soto, Juan F. Santibanez, Cesar Echeverria

Research output: Contribution to journal › Article › peer-review

Abstract

Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.

Translated title of the contribution	Relaciones entre las caracteristicas estructurales de las curcuminas que afectan la proliferacion celular de las celulas de hepatocarcinoma
Original language	English
Pages (from-to)	174-179
Number of pages	6
Journal	Afinidad
Volume	80
Issue number	599
DOIs	https://doi.org/10.55815/417980
State	Published - 2023
Externally published	Yes

Access to Document

10.55815/417980

Cite this

@article{ac4a7ef1d7af4c6e854504eafc877336,

title = "Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells",

abstract = "Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.",

author = "Rodrigo Ramirez-Tagle and Leonor Alvarado-Soto and Santibanez, {Juan F.} and Cesar Echeverria",

year = "2023",

doi = "10.55815/417980",

language = "English",

volume = "80",

pages = "174--179",

journal = "Afinidad",

issn = "2339-9686",

number = "599",

}

TY - JOUR

T1 - Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells

AU - Ramirez-Tagle, Rodrigo

AU - Alvarado-Soto, Leonor

AU - Santibanez, Juan F.

AU - Echeverria, Cesar

PY - 2023

Y1 - 2023

N2 - Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.

AB - Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.

UR - http://www.scopus.com/inward/record.url?scp=85173734115&partnerID=8YFLogxK

U2 - 10.55815/417980

DO - 10.55815/417980

M3 - Article

AN - SCOPUS:85173734115

SN - 2339-9686

VL - 80

SP - 174

EP - 179

JO - Afinidad

JF - Afinidad

IS - 599

ER -

Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells

Abstract

Access to Document

Other files and links

Fingerprint

Cite this