Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells

Rodrigo Ramirez-Tagle; Leonor Alvarado-Soto; Juan F. Santibanez; Cesar Echeverria

doi:10.55815/417980

Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells

Título traducido de la contribución: Relaciones entre las caracteristicas estructurales de las curcuminas que afectan la proliferacion celular de las celulas de hepatocarcinoma

Rodrigo Ramirez-Tagle, Leonor Alvarado-Soto, Juan F. Santibanez, Cesar Echeverria

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.

Título traducido de la contribución	Relaciones entre las caracteristicas estructurales de las curcuminas que afectan la proliferacion celular de las celulas de hepatocarcinoma
Idioma original	Inglés
Páginas (desde-hasta)	174-179
Número de páginas	6
Publicación	Afinidad
Volumen	80
N.º	599
DOI	https://doi.org/10.55815/417980
Estado	Publicada - 2023
Publicado de forma externa	Sí

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title = "Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells",

abstract = "Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.",

author = "Rodrigo Ramirez-Tagle and Leonor Alvarado-Soto and Santibanez, {Juan F.} and Cesar Echeverria",

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AU - Ramirez-Tagle, Rodrigo

AU - Alvarado-Soto, Leonor

AU - Santibanez, Juan F.

AU - Echeverria, Cesar

PY - 2023

Y1 - 2023

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AB - Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relationship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.

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Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells

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